Top 8 Best Methylfolate Supplements for MTHFR (2024)

This dietary supplement has been a subject of discussion in the recent past because of its potential benefits in boosting human health. In particular, people with MTHFR gene mutations might need to take methylfolate to help the body properly metabolize folic acid.

The following are some of the most important factors that you need to consider when searching for the right methylfolate supplement for MTHFR. To begin with, one has to identify a supplement that includes the active form of folate – L-methylfolate. Furthermore, it is important to consider the frequency and type of the supplement, including capsules or tablets.

In our team, we know where to look for the right methyl folate supplement for MTHFR. That is why we took our time to look for the various supplements on the market and tried them out to find the best ones. In the subsequent sections, we will give our recommendation and detailed evaluation for selecting the right product.

Top 3 Best Methylfolate Supplements for MTHFR

1. Nature's Fusions Methylated Folate Supplement
2. Mama's Select Methylfolate MTHFR Folate
3. Codeage Methylfolate B Complex Supplements

We have looked for and tried different methylfolate supplements that can assist individuals with MTHFR gene abnormalities. Methylfolate is crucial for the conversion of hom*ocysteine, an amino acid that when accumulated can cause health issues. This is why we have done our research to provide you with the best methylfolate supplement for MTHFR that will suit your requirements. When making a recommendation, we consider the product in terms of effectiveness, purity, and customer feedback.

Especially for those who seek a bioavailable and pure source of folate to support their health, we strongly suggest the Nature’s Fusions Methylated Folate Supplement.

Pros

• The 15mg per serving is a superior strength and highly effective formula for optimal support of your body's methylation processes.
• The 120 vegan tablets per bottle provide a generous supply and cater to specific dietary preferences while offering maximum efficacy.
• The bioactive form of folic acid, 5-methyltetrahydrofolate (5-MTHF), is highly bioavailable and pure, ensuring efficient absorption and utilization.

Cons

• The tablets may be small and uncoated, which may make them difficult to swallow for some individuals.
• The price point may be higher compared to other methylfolate supplements on the market.
• The supplement may not be suitable for individuals with certain medical conditions or taking certain medications, so it is important to consult with a healthcare provider before use.

To sum up, Mama’s Select Methylfolate MTHFR Folate is a great choice if you are searching for a highly bioavailable and superior methylfolate supplement for MTHFR gene mutation.

Pros

• Formulated for pregnant and lactating mothers
• Superior Methylfolate formula on the market
• Supports fetal development including brain development, healthy cell growth, and spinal development

Cons

• Large capsule size
• May cause mild digestive discomfort
• Only 90 capsules per bottle

For those of you seeking a comprehensive methylation supplement that comes with folate, methylated vitamins, riboflavin, and betaine in capsule form, Codeage Methylfolate B Complex Supplements is our top pick.

Pros

• The supplement offers an all-in-one methylation supplement with folate, methylated vitamins, riboflavin, and betaine in an easy-to-use capsule format.
• The formula contains 1360 mcg of 5- MTHF folate with Quatrefolic 5 methylfolate and glucosamine salt as a folate supplement. It also contains 30 mg of Riboflavin 5’- Phosphate as a riboflavin supplement.
• The blend features 600 mg of betaine as trimethylglycine (TMG). The vitamins included in this formula (vitamin B6 and vitamin B12 1000 mcg) are also provided in their phosphorylated forms.

Cons

• The supplement may cause nausea if taken before a meal.
• The product may not be suitable for those with an egg allergy.
• The price is on the higher side.

For anyone interested in obtaining a methylfolate supplement of superior quality this product is highly recommended.

Pros

• Take The Right Kind Of Folate - Our bodies have a reduced ability to convert folic acid to 5-MTHF, the activated form of folate. This supplement provides the bioavailable form of folate, L-Methylfolate, for direct absorption and support.
• Bioavailable Mood Support - L-Methylfolate is the only form of folate to cross the blood-brain barrier, making it a more active and effective brain supplement for mood support.
• Cardiovascular, Nerve, & Mood Support - Methylated folate is essential for the production of neurotransmitters like serotonin, norepinephrine, and dopamine, as well as overall nerve and cardiovascular maintenance.

Cons

• Capsule Size - Some users may find the capsule size to be larger than they prefer.
• Price - This product is a bit more expensive compared to other methylfolate supplements on the market.
• Dosage - The recommended dosage is 1 capsule per day, which may not be enough for some individuals who require a higher dose.

If you are seeking for methylfolate supplement for MTHFR, then MD. LIFE L-Methylfolate 7. I believe 5 mg is a good choice.

Pros

• This supplement contains active folate that works by providing your body with the necessary ingredients to properly utilize folic acid.
• Methylfolate 7.5 mg is essential for the production and maintenance of new cells, making it a great choice for those looking for synthesis and repair support.
• This supplement is third-party tested for purity, ensuring the highest level of quality and compliance with safety and performance standards.

Cons

• The unflavored capsule may be difficult to swallow for some.
• Some users may experience mild side effects such as nausea or headaches.
• This supplement may not be suitable for those with certain medical conditions or taking certain medications.

This has been a positive experience with MD. LIFE L-Methylfolate 7. 5 mg. The active folate in this supplement has improved our energy levels and alertness, as well as our mood and hormonal balance. We understand that this product undergoes third-party purity testing, which makes us feel more secure about the quality of the supplement. But in general, we wanted the capsule to go down easier and for the supplement to be better for people with certain health issues or those who take medications. In conclusion, we would like to state that MD should be preferred. LIFE L-Methylfolate 7. 5 mg to anyone seeking for a quality methylfolate for MTHFR supplement.

NatureGenX Methylation Protect w/Active B12 with L-5-MTHF is the best natural and effective supplement to support MTHFR.

Pros

• Provides the most stable, bioavailable, and active form of folate and vitamin B12
• Ideal for those with MTHFR Gene Mutation
• Boosts your energy and supports complete cellular health

Cons

• The taste may not be for everyone
• May not work for everyone
• A bit pricey

If you have been searching for a strong methylfolate that can improve your mood, brain, and overall health then MD. Life L-Methylfolate 5mg is a product worth recommending.

Pros

• This supplement contains active folate that works effectively without the need for the MTHFR enzyme.
• Methylfolate 5 mg is essential for the production and maintenance of new cells, making it great for synthesis and repair.
• MD.LIFE L-Methylfolate 5 mg is third-party tested for purity, ensuring the highest level of quality and safety.

Cons

• The capsules are unflavored, which may not be appealing to some users.
• This supplement contains a high dose of methylfolate, which may not be suitable for everyone.
• Some users may experience mild side effects such as nausea or headaches.

As for MTHFR, Intelligent Labs 1MG 5-MTHF Methylfolate is one of the best methylfolate supplements available out there.

Pros

• Pure 5-MTHF for MTHFR issues
• 4th generation activated folate for better absorption
• Quatrefolic acid for trademarked supplement 5-MTHF

Cons

• Capsules may vary in fill levels
• May not work for everyone
• Some users may experience side effects

Buying Guide

In order to get the best methylfolate supplement containing MTHFR, there are some factors that one has to consider so as to be in a position to choose the best supplement in the market. Here are some factors to keep in mind when making your selection:

Form of Methylfolate

The available methylfolate supplements include capsules, tablets, and powders. The most familiar ones are capsules and tablets, which are easy to swallow and can be taken anywhere. It is dissolved in water or other liquids which may be preferred by those who have problems in taking tablets. Think about your preference and metabolism when deciding which methylfolate form suits your needs the most.

Dosage

Depending on the severity of the deficiency, the dose can be different, so it is critical to select the best methylfolate supplement. The recommended dose will vary with factors including age, sex, and the overall health of the patient. It is always advisable to seek the advice of a healthcare provider to establish the ideal dosage to take.

Quality and Purity

When selecting methylfolate supplement, it is advisable to select one that is of high quality and does not contain any impurities. Search for supplements that are manufactured by reputable companies and tested for their quality and content by a third party. You can also look for badges like Good Manufacturing Practices (GMP) to confirm that the product has gone through rigorous production standards.

Other Ingredients

Avoid any supplement that has other substances such as fillers, binders, or artificial coloration and flavoring. Some people may have some sensitivities or allergies to some ingredients and therefore a product that has such ingredients should be avoided.

Price

When choosing methylfolate supplements, you should determine their cost, which may also significantly differ. Do not assume that the items in the store whose prices are relatively higher are of better quality, so compare and contrast the prices and the quality of the products.

Frequently Asked Questions About the Best Digestive Enzymes

1. What is the recommended dosage of methylfolate for MTHFR mutation?

The dose of methylfolate for patients with MTHFR mutation depends on the degree of the mutation. It is advised to seek the advice of a doctor when trying to identify the right dosage to take.

2. What are the benefits of taking a 5-MTHF supplement?

Supplementing with 5-MTHF can promote the health of methylation and DNA synthesis processes. In addition, it may be useful in enhancing mood and cognitive performance.

3. Can individuals with MTHFR gene mutation take methylfolate?

Of course, people with MTHFR gene mutation can take methylfolate. Indeed, it is suggested to be taken as a means of encouraging healthy methylation.

4. What is the difference between L-5-Methyltetrahydrofolate and folic acid?

L-5-Methyltetrahydrofolate is one of the active forms of folate that is utilizable in the human body. Although folic acid must be converted to L-5-Methyltetrahydrofolate before it can be utilized in the body.

5. Are there any recommended multivitamins for individuals with MTHFR mutation?

Some of the multivitamins that are available in the market are designed for patients suffering from MTHFR mutation. One must ensure that the multivitamin has the bioactive form of folic acid, preferably L-5-Methyltetrahydrofolate.

6. What are the benefits of taking L-5-Methyltetrahydrofolate over L-Methylfolate?

L-5-Methyltetrahydrofolate is one of the forms of folate that is utilizable in the body. In contrast, L-Methylfolate requires conversion to L-5-Methyltetrahydrofolate for utilization in the body. Thus, the use of L-5-Methyltetrahydrofolate may provide better improvement of the methylation process.